Cancer Genomics in the Brain

How do we leverage the increasing amount of genetics and genomics data to better diagnose, classify and treat brain tumors? We investigated the ancestry-based genomic signature differences in patients with malignant brain tumors and the implications of clinical trial designs in these incurable diseases¹. We also looked at various biomarkers that can non-invasively but accurately diagnose, prognose and classify brain tumors including viral infection history, hematological parameters and immune system parameters. These studies collectively contributed to personalized and minimally-invasive diagnostic processes of malignant brain tumors in the future and point to more effective patient stratification strategies for clinical trials.

Figure 1. Genomic Signatures of Glioblastoma.